Jose Mourinho returned to Manchester United and humiliated his former club as Tottenham came from behind to record a famous Old Trafford win.
United took an early lead in the second minute when Marcus Rashford was brought down in the penalty box and Bruno Fernandes coolly slotted home the spot-kick to seemingly give the home side the perfect start.
However that lead did not last long though as Son Heung-min and Harry Kane scored twice as Spurs opened up a disorganised United defence at will even before Anthony Martial was harshly shown a red card for an off-ball clash with Erik Lamela.
Tanguy Ndombele and Serge Aurier were also on also on target as 10-man United suffered a defeat on a par with their 6-1 thrashing at home by Manchester City in 2011.
It meant it was not only the heaviest defeat since Ole Gunnar Solskjaer took temporary charge in December 2018, but also the largest United have suffered since Ed Woodward took over as executive vice-chairman in 2013.
The result leaves United 16th in the Premier League, with newly promoted Fulham and West Brom the only clubs with a worse goal difference. Only West Brom have conceded more than their 11 goals.
United were completely outplayed, especially at the back as Eric Bailly, Harry Maguire, Luke Shaw and Aaron Wan-Bissaka were unable to handle Tottenham’s attacking pressure.
In contrast, Tottenham moved up to fifth after emerging from a packed schedule of five games in 11 days in three competitions with a creditable four wins and a draw.